Head And Neck Cancer Pipeline Analysis: 130+ Companies are Working to Improve the Treatment Space | DelveInsight

November 07 22:05 2022
Head And Neck Cancer Pipeline Analysis: 130+ Companies are Working to Improve the Treatment Space | DelveInsight

DelveInsight’s, “Head and Neck cancer Pipeline Insight, 2022,” report provides comprehensive insights about 130+ companies and 150+ pipeline drugs in the Head and Neck cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

Key takeaways from the Head and Neck Cancer Pipeline Report

  • DelveInsight’s Head and Neck cancer Pipeline report depicts a robust space with 130+ active players working to develop 150+ pipeline therapies for Head and Neck cancer.
  • The leading Head and Neck Cancer Companies such as Innate Pharma, GlaxoSmithKline, Debiopharm, Checkpoint Therapeutics, Quadriga BioSciences, Palleon Pharmaceuticals, Klus Pharma, Bicycle Therapeutics, CSPC ZhongQi Pharmaceutical Technology, Memgen, I-Mab Biopharma, Intensity Therapeutics, Wellmaker Bio, SN BioScience, Carisma Therapeutics, Genentech, Pionyr Immunotherapeutics, Palleon Pharmaceuticals, SN BioScience, Bicycle Therapeutics, Inhibrx, Celldex Therapeutics, Carisma Therapeutics Inc, BioAtla, Jacobio Pharmaceuticals, Compugen, GeoVax, CytomX Therapeutics, PNP Therapeutics, Galectin Therapeutics, Cyteir Therapeutics, Merck KGaA, Boehringer Ingelheim, Transgene, iTeos Therapeutics SA,  IntraGel Therapeutics, Incyte Corporation, Cue Biopharma, Rubius Therapeutics, Alkermes, Corregene Biotechnology, NanoCarrier, Kura Oncology, Betta Pharmaceuticals, Arcus Biosciences, Taiho Pharmaceutical, Astex Pharmaceuticals, Bayer HealthCare, Roche, Vaccinex, Pfizer, BioNTech,  Purple Biotech, Novartis Oncology, Macrogenics, Aveta Biomics, Cellectar Biosciences, Nanobiotix, Nektar Therapeutics, Istari Oncology, Nanobiotix, Aspyrian Therapeutics, and others are evaluating new head and neck cancer drugs to improve the treatment landscape.
  • Promising Head and Neck Cancer Pipeline Therapies such as Niraparib, Xevinapant, , CK-301, QBS10072S, A166, E-602, BT5528, RAPA-201, Mitoxantrone Hydrochloride, MEM-288, TJ004309, SNB-101, INT230-6, CT-0508, WM-S1-030, CDX-1140, PY159, MCLA-129, INBRX-106, Autogene cevumeran, JAB-3068, CAB-ROR2-ADC, CX-2029, Ad/PNP, COM701, Eftilagimod alpha, CYT-0851, GR-MD-02, TG4050, BI 765063, TumoCure, EOS-448, Epacadostat, RTX-321, CUE-101, ALKS 4230, CRTE7A2-01, NC-6004, Tipifarnib, MCLA-129, Zimberelimab, HLX10 Plus HLX07, Tolinapant, BAY1905254, OSI-774, VX15/2503, Palbociclib, Olaparib, NT219, BNT113, Buparlisib, Retifanlimab, Avelumab, APG-157, CLR 131, NBTXR3, Evorpacept, Dostarlimab, NKTR-214, IK-175, Lerapolturev, NBTXR3, Gedeptin, RM-1995, Atezolizumab and others are under different phases of head and neck cancer clinical trials.
  • In the coming years, the Head and Neck cancer market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies and academics that are working to assess challenges and seek opportunities that could influence Head and Neck cancer R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.

 

Get an overview of the Head and Neck cancer Pipeline landscape @ Head and Neck cancer Emerging Therapies

 

Head and Neck Cancer Overview

Head and neck cancer is a collective term that includes several different types of cancers. Cancers of the head and neck are categorized by the area in which they begin. This includes the mouth (oral cavity), throat (pharynx), voice box (larynx), sinuses and nose cavity, and salivary glands. The most common type of head and neck cancer is squamous cell carcinoma of the head and neck (HNSCCA). Most HNSCCA begins in the layer of flat cells (the epithelium) which line the structures of the upper aerodigestive tract, including the mouth, throat, and voice box.

 

Latest Breakthroughs of Head and Neck Cancer Treatment Landscape

  • In September 2022, NANOBIOTIX announced randomization of the first patient in Asia in NANORAY-312, a global Phase III registrational trial evaluating NBTXR3 for the treatment of elderly patients with locally advanced head and neck squamous cell carcinoma who are ineligible for platinum-based chemotherapy.
  • In August 2022, Genexine announced the dosing of the first patient in Phase II clinical trial using triple combination therapy in patients with recurrent/metastatic HNSCC. The combination therapy consists of two of Genexine’s proprietary drugs, GX-188E (a first-in-class therapeutic DNA vaccine), GX-I7 (a first-in-class long-acting interleukin 7), and Opdivo (nivolumab), a marketed PD-1 immune checkpoint inhibitor.
  • In May 2022, Calliditas announced that it had initiated Phase II head and neck cancer therapy trial. The trial will analyze the impact of setanaxib plus pembrolizumab in patients with CAF-density tumors. Calliditas Therapeutics has randomized the first subject in the proof-of-concept Phase II clinical trial of setanaxib (GKT831) in individuals with squamous cell carcinoma of the head and neck (SCCHN).
  • In May 2022, Exelixis announced results from a phase II, the investigator-sponsored trial of cabozantinib (CABOMETYX®) in combination with pembrolizumab in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). The trial met its primary endpoint of objective response rate per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 at 54%. The overall clinical benefit rate was 91%. At a median follow-up of 10.6 months, the one-year progression-free survival rate was 54.0% (95% confidence interval [CI]: 31.5-72.0%), and median progression-free survival was 14.6 months. The one-year overall survival (OS) rate was 68.4% (95% CI: 45.1-83.5%; median OS: 22.3 months).
  • In January 2022, The FDA accepted an investigational new drug application for the photoimmunotherapy treatment, RM-1995, for patients with advanced cutaneous squamous cell carcinoma or head and neck squamous cell carcinoma.
  • In February 2021, The Food and Drug Administration (FDA) granted Breakthrough Therapy designation to tipifarnib for the treatment of patients with recurrent or metastatic HRAS mutant head and neck squamous cell carcinoma with variant allele frequency greater than or equal to 20% after disease progression on platinum-based chemotherapy.

 

Request a sample and discover the recent advances in head and neck cancer treatment drugs @ Head and Neck Cancer Pipeline Report

 

Head and Neck Cancer Emerging Drugs

  • Monalizumab: Innate Pharma
  • Niraparib: GlaxoSmithKline
  • Xevinapant: Debiopharm
  • Enoblituzumab: MacroGenics

 

DelveInsight’s Head and Neck Cancer Pipeline Report covers around 150+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates

 

Learn more about the emerging head and neck cancer pipeline therapies @ Head and Neck Cancer Clinical Trials

 

Scope of the Head and Neck Cancer Pipeline Report 

  • Coverage: Global
  • Head and Neck Cancer Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
  • Head and Neck Cancer Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
  • Head and Neck Cancer Therapeutics Assessment By Route of Administration: Inhalation, Intranasal, Intravenous, Oral, Parenteral, Subcutaneous
  • Head and Neck Cancer Therapeutics Assessment By Molecule Type: Antibody, Antisense oligonucleotides, Immunotherapy, Monoclonal antibody, Peptides, Protein, Recombinant protein, Small molecule, Stem cell, Vaccine
  • Head and Neck Cancer Therapeutics Assessment By Mechanism of Action: Antibody-dependent cell cytotoxicity, NK cell lectin-like receptor subfamily C antagonists, Poly(ADP-ribose) polymerase 1 inhibitors, Poly(ADP-ribose) polymerase 2 inhibitors, Inhibitor of apoptosis protein inhibitors, T lymphocyte stimulants, Aryl hydrocarbon receptor antagonists, DNA topoisomerase I inhibitors; CD40 ligand expression stimulants; Cell death stimulants; Immunologic cytotoxicity, Galectin 3 inhibitors, CD40 antigen stimulants
  • Key Head and Neck Cancer Companies: Innate Pharma, GlaxoSmithKline, Debiopharm, Checkpoint Therapeutics, Quadriga BioSciences, Palleon Pharmaceuticals, Klus Pharma, Bicycle Therapeutics, CSPC ZhongQi Pharmaceutical Technology, Memgen, I-Mab Biopharma, Intensity Therapeutics, Wellmaker Bio, SN BioScience, Carisma Therapeutics, Genentech, Pionyr Immunotherapeutics, Palleon Pharmaceuticals, SN BioScience, Bicycle Therapeutics, Inhibrx, Celldex Therapeutics, Carisma Therapeutics Inc, BioAtla, Jacobio Pharmaceuticals, Compugen, GeoVax, CytomX Therapeutics, PNP Therapeutics, Galectin Therapeutics, Cyteir Therapeutics, Merck KGaA, Boehringer Ingelheim, Transgene, iTeos Therapeutics SA,  IntraGel Therapeutics, Incyte Corporation, Cue Biopharma, Rubius Therapeutics, Alkermes, Corregene Biotechnology, NanoCarrier, Kura Oncology, Betta Pharmaceuticals, Arcus Biosciences, Taiho Pharmaceutical, Astex Pharmaceuticals, Bayer HealthCare, Roche, Vaccinex, Pfizer, BioNTech,  Purple Biotech, Novartis Oncology, Macrogenics, Aveta Biomics, Cellectar Biosciences, Nanobiotix, Nektar Therapeutics, Istari Oncology, Nanobiotix, Aspyrian Therapeutics and others.
  • Key Head and Neck Cancer Pipeline Therapies: Niraparib, Xevinapant, , CK-301, QBS10072S, A166, E-602, BT5528, RAPA-201, Mitoxantrone Hydrochloride, MEM-288, TJ004309, SNB-101, INT230-6, CT-0508, WM-S1-030, CDX-1140, PY159, MCLA-129, INBRX-106, Autogene cevumeran, JAB-3068, CAB-ROR2-ADC, CX-2029, Ad/PNP, COM701, Eftilagimod alpha, CYT-0851, GR-MD-02, TG4050, BI 765063, TumoCure, EOS-448, Epacadostat, RTX-321, CUE-101, ALKS 4230, CRTE7A2-01, NC-6004, Tipifarnib, MCLA-129, Zimberelimab, HLX10 Plus HLX07, Tolinapant, BAY1905254, OSI-774, VX15/2503, Palbociclib, Olaparib, NT219, BNT113, Buparlisib, Retifanlimab, Avelumab, APG-157, CLR 131, NBTXR3, Evorpacept, Dostarlimab, NKTR-214, IK-175, Lerapolturev, NBTXR3, Gedeptin, RM-1995, Atezolizuma, and others.

 

Dive deep into rich insights for new drugs for head and neck cancer treatment, visit @ Head and Neck Cancer Drugs

 

Table of Content

  1. Introduction
  2. Executive Summary
  3. Head and Neck cancer: Overview
  4. Pipeline Therapeutics
  5. Therapeutic Assessment
  6. Head and Neck cancer – DelveInsight’s Analytical Perspective
  7. Late Stage Products (Phase III)
  8. Monalizumab: Innate Pharma
  9. Mid Stage Products (Phase II)
  10. Enoblituzumab: MacroGenics
  11. Early Stage Products (Phase I)
  12. IK-175: Ikena Oncology
  13. Preclinical and Discovery Stage Products
  14. Research programme: cancer vaccines – Voltron Therapeutics
  15. Inactive Products
  16. Head and Neck cancer Key Companies
  17. Head and Neck cancer Key Products
  18. Head and Neck cancer- Unmet Needs
  19. Head and Neck cancer- Market Drivers and Barriers
  20. Head and Neck cancer- Future Perspectives and Conclusion
  21. Head and Neck cancer Analyst Views
  22. Head and Neck cancer Key Companies
  23. Appendix

 

For further information on the head and neck cancer pipeline therapeutics, reach out @ Head and Neck Cancer Treatment Drugs

 

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