DelveInsight’s, “Clostridium Difficile Infections (Clostridium Difficile Associated Disease) Pipeline Insight, 2022” report provides comprehensive insights about 25+ companies and 25+ pipeline drugs in Clostridium Difficile Infections (Clostridium Difficile Associated Disease) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Key takeaways from the Clostridium Difficile Infections Pipeline Insight Report
Recent Developmental Activities in the Clostridium Difficile Infections Pipeline
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Clostridium Difficile Infections Overview
Clostridium difficile infection (CDI) is acute diarrhea and colitis that is most often preceded by antimicrobial use and is caused by an anaerobic spore-forming, toxin-producing bacterium. C. difficile is found in water, soil, meats, and vegetables and is particularly common in health care environments, where the spores are difficult to eradicate. Patients are exposed to and ingest C. difficile spores in the health care setting from contact with the environment or health care workers who do not practice good hand hygiene. Clostridium difficile infection is the most common cause of hospital acquired diarrhea and carries significant morbidity and mortality. Current treatment options are limited by high rates of recurrence, and fecal transplantation has proven to be an effective and safe option, with very low rates of recurrence. Initial treatment of CDI involves discontinuation of any nonvital antibiotic therapy and administration of fluid and electrolyte replacement. For mild cases, this treatment may be curative. Persistent symptoms or moderate to severe disease warrant antimicrobial therapy directed against C.difficile. Oral metronidazole remains the first-line therapy for mild to moderate CDI in children. For more severe infection, oral vancomycin is approved by the U.S. Food and Drug Administration (FDA) for CDI. Diagnosis of CDI is based on the presence of clinical symptoms (usually defined as more than three watery, loose or unformed stools within ≤24 hours) coupled with a diagnostic test (usually of a stool specimen) that either detects the presence of the C. difficile organism or its toxin genes or detects C. difficile toxin using an enzyme immunoassay or cell cytotoxin assay. The first steps in effective treatment are to stop any therapy with the offending antibiotic and provide fluid and electrolyte support, if needed. Prevention in the health care environment is focused on preventing patient exposure to spores of C. difficile by utilizing isolation, cohorting, gloves and gowns, and hand washing (alcohol rubs are ineffective against spores). Bleach is used in the environment to eradicate spores. It is exceedingly difficult to prevent spore exposure, so antimicrobial stewardship programs to reduce unnecessary antimicrobial use are extremely effective in limiting the number of susceptible patients.
Clostridium Difficile Infections Pipeline Report
In the Clostridium difficile infection pipeline report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Clostridium Difficile Infections(Clostridium Difficile Associated Disease) collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Clostridium Difficile Infections Emerging Drugs Profile
Clostridium Difficile Infections Pipeline Therapeutic Analysis
There are approx. 25+ key companies which are developing the therapies for Clostridium Difficile Infections (Clostridium Difficile Associated Disease). The companies which have their Clostridium Difficile Infections (Clostridium Difficile Associated Disease) drug candidates in the most advanced stage, i.e. Pre-Registration include, Rebiotix.
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Clostridium Difficile Infections Therapeutics Assessment
The Clostridium Difficile Infections pipeline report proffers an integral view of the Clostridium Difficile Infections emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.
Scope of the Clostridium Difficile Infections Pipeline Insight Report
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Table of Content
Key Questions
Current Treatment Scenario and Emerging Therapies:
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